some biomarkers in acute myocardial infarction

background: several changes in serum biochemical factors occur in acute myocardial infarction (ami). recently alterations in serum levels of homocysteine (hcy), sialic acid (sa) and high sensitive c-reactive protein (hs-crp) has been attended as risk factors and index for prediction. this study was aimed to show the alterations in these factors and their relationships in ami. methods: thirty four patients with ami were enrolled in this case-control study. also 51 apparently healthy individuals were selected as control group. serum was prepared from all subjects in fasting state. hcy and hs-crp were measured using elisa and sa was determined by erlich method. results: serum levels of hcy, sa and hs-crp in ami patients were 14.35â±2.55î¼mol/l, 73.54â±2.82 mg/dl, and 17.32â±3.45 mg/l, respectively and in the control group they were 8.31â±2.66 î¼mol/l, 59.82â±2.70 mg/dl and 2.77â±1.98 mg/l, respectively. statistical analysis of data showed that serum level of hcy, sa, and hs-crp in the patients with ami was significantly higher than those of control ( p p conclusion: our findings showed increased level of hs-crp, sa, and hcy in ami patients. also obtained data indicated a direct and significant correlation between hs-crp as an inflammation index and hcy and sa. hence these two factors can be used as biomarkers in this disease.